pysam-developers/pysam

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

GitHub repository with 893 stars and 298 forks.

Language: Cython

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2026-06-06: 893 stars and 298 forks.

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