Claude Code skills for medical research — literature search, reporting guidelines, statistical analysis, publication figures. Built by a physician-researcher, tested on real publications. MIT licensed.
GitHub repository with 148 stars and 37 forks.
Language: Python
Topics: agent-skills, biostatistics, claude-code, claude-skills, clinical-research, diagnostic-accuracy, irb-protocol, literature-review, manuscript, medical-ai
Trending score 1.23, freshness score 0.98, stars gained +2, forks gained +0.
2026-06-15: 148 stars and 37 forks.
SkillOpt is a text-space optimizer that trains reusable natural-language skills for frozen LLM agents through trajectory-driven edits, validation-gated updates, and deployable best_skill.md artifacts.
GitHub repository with 6,977 stars and 669 forks.
Trending score: 5.18; stars gained: +667; forks gained: +56.
Language: Python
Topics: agent-skills, self-evolving-agents
Framework for AI agents to build and maintain a digital brain through Obsidian wiki using Karpathy's LLM Wiki pattern
GitHub repository with 2,034 stars and 216 forks.
Trending score: 4.01; stars gained: +177; forks gained: +11.
Language: Python
Topics: agent-skills, brain, knowledge-base, llm-tools, obsidian, obsidian-brain
Community-contributed instructions, agents, skills, and configurations to help you make the most of GitHub Copilot.
GitHub repository with 35,025 stars and 4,314 forks.
Trending score: 3.92; stars gained: +91; forks gained: +17.
Language: Python
Topics: ai, github-copilot, prompt-engineering, hacktoberfest, agent-skills, agents
Multi-harness agentic plugin marketplace for Claude Code, Codex CLI, Cursor, OpenCode, GitHub Copilot, and Gemini CLI
GitHub repository with 36,760 stars and 3,977 forks.
Trending score: 3.75; stars gained: +107; forks gained: +9.
Language: Python
Topics: agents, anthropic, automation, workflows, orchestration, agent-skills
把中文全渠道内容（抖音 / B站 / 小红书 / 公众号 / X / 播客）采集进个人知识库的 13 个 AI Skill：图文存图、视频转文字稿、字幕优先免 GPU，附带知识库 MCP server。 ｜ Ingest Chinese content into your personal knowledge base — image/video routing, subtitle-first transcription, and a KB MCP server.
GitHub repository with 342 stars and 51 forks.
Trending score: 3.56; stars gained: +52; forks gained: +3.
Language: Python
Topics: agent-skills, ai-agents, chinese, claude-code, knowledge-base, mcp
Hundreds of agent skills for medical research, including protocol design, data analysis, evidence insights, and academic writing.
GitHub repository with 1,131 stars and 77 forks.
Trending score: 3.22; stars gained: +42; forks gained: +0.
Language: Python
Topics: academic-writing, agent-skills, ai, bioinformatics, biology, cancer-genomics
Compress tool outputs, logs, files, and RAG chunks before they reach the LLM. 60-95% fewer tokens, same answers. Library, proxy, MCP server.
GitHub repository with 27,902 stars and 1,891 forks.
Trending score: 6.49; stars gained: +2,776; forks gained: +250.
Language: Python
Topics: agent, ai, anthropic, claude-code, compression, context-engineering
利用AI大模型，一键生成高清短视频 Generate short videos with one click using AI LLM.
GitHub repository with 88,027 stars and 12,625 forks.
Trending score: 6.02; stars gained: +1,097; forks gained: +218.
Language: Python
Topics: ai, automation, chatgpt, moviepy, python, shortvideo
Self-hosted AI workspace.
GitHub repository with 71,300 stars and 9,086 forks.
Trending score: 5.98; stars gained: +834; forks gained: +140.
Language: Python
The agent that grows with you
GitHub repository with 193,883 stars and 33,934 forks.
Trending score: 5.92; stars gained: +753; forks gained: +209.
Language: Python
Topics: ai, ai-agent, ai-agents, anthropic, chatgpt, claude
Security scanner for AI agent skills. Detect vulnerabilities, malicious patterns, and security risks.
GitHub repository with 5,654 stars and 427 forks.
Trending score: 5.61; stars gained: +874; forks gained: +76.
Language: Python
Learn it. Build it. Ship it for others.
GitHub repository with 32,527 stars and 5,342 forks.
Trending score: 5.59; stars gained: +762; forks gained: +135.
Language: Python
Topics: agents, ai, ai-agents, ai-engineering, computer-vision, course
🎨 Local-first, open-source Claude Design alternative. 🖥️ Native desktop app. ⚡ 259+ Skills · ✨ 142+ Design Systems 🖼️ Web · desktop · mobile prototypes · slides · images · videos · HyperFrames 📦 Sandboxed preview · HTML/PDF/PPTX/MP4 export 🤖 Claude Code / OpenClaw / Codex / Cursor / OpenCode / Qwen / Copilot / Hermes / Kimi & 17+ CLIs.
GitHub repository with 65,109 stars and 7,294 forks.
Trending score: 5.65; stars gained: +790; forks gained: +117.
Language: TypeScript
Topics: agent-skills, ai-agents, ai-design, byok, claude-code-for-design, claude-design
SkillOpt is a text-space optimizer that trains reusable natural-language skills for frozen LLM agents through trajectory-driven edits, validation-gated updates, and deployable best_skill.md artifacts.
GitHub repository with 6,977 stars and 669 forks.
Trending score: 5.18; stars gained: +667; forks gained: +56.
Language: Python
Topics: agent-skills, self-evolving-agents
A lightweight, lightning-fast, in-process vector database
GitHub repository with 10,064 stars and 583 forks.
Trending score: 4.23; stars gained: +283; forks gained: +17.
Language: C++
Topics: agent-skills, db, embedded, faiss, hnsw, llm-memory
Run Claude Design locally as an Agent Skill — Cursor, Claude Code & more. Produce polished UI mockups, prototypes, decks & wireframes as self-contained HTML, without claude.ai/design. Best with Opus 4.8.
GitHub repository with 1,108 stars and 79 forks.
Trending score: 4.13; stars gained: +137; forks gained: +5.
Language: JavaScript
Topics: agent-skills, claude, claude-code, claude-design, cursor, design
Framework for AI agents to build and maintain a digital brain through Obsidian wiki using Karpathy's LLM Wiki pattern
GitHub repository with 2,034 stars and 216 forks.
Trending score: 4.01; stars gained: +177; forks gained: +11.
Language: Python
Topics: agent-skills, brain, knowledge-base, llm-tools, obsidian, obsidian-brain
Community-contributed instructions, agents, skills, and configurations to help you make the most of GitHub Copilot.
GitHub repository with 35,025 stars and 4,314 forks.
Trending score: 3.92; stars gained: +91; forks gained: +17.
Language: Python
Topics: ai, github-copilot, prompt-engineering, hacktoberfest, agent-skills, agents