Python repositories

Discover trending Python repositories ranked by recent growth and activity.

  1. 1. NousResearch/hermes-agent

    The agent that grows with you

    GitHub repository with 181,303 stars and 31,111 forks.

    Trending score: 5.95; stars gained: +1,867; forks gained: +361.

    Language: Python

    Topics: ai, ai-agent, ai-agents, anthropic, chatgpt, claude

  2. 2. chopratejas/headroom

    Compress tool outputs, logs, files, and RAG chunks before they reach the LLM. 60-95% fewer tokens, same answers. Library, proxy, MCP server.

    GitHub repository with 12,930 stars and 833 forks.

    Trending score: 5.69; stars gained: +2,829; forks gained: +175.

    Language: Python

    Topics: agent, ai, anthropic, claude-code, compression, context-engineering

  3. 3. Imbad0202/academic-research-skills

    Academic Research Skills for Claude Code: research → write → review → revise → finalize

    GitHub repository with 27,327 stars and 2,249 forks.

    Trending score: 5.52; stars gained: +1,079; forks gained: +89.

    Language: Python

    Topics: academic-pipeline, academic-writing, ai-research, claude, claude-code, literature-review

  4. 4. anthropics/financial-services

    GitHub repository with 29,986 stars and 4,219 forks.

    Trending score: 4.88; stars gained: +688; forks gained: +114.

    Language: Python

  5. 5. virgiliojr94/book-to-skill

    Turn any technical book PDF into a Claude Code skill — ready to study, reference, and use while you work.

    GitHub repository with 4,221 stars and 528 forks.

    Trending score: 4.88; stars gained: +476; forks gained: +68.

    Language: Python

  6. 6. vinta/awesome-python

    An opinionated list of Python frameworks, libraries, tools, and resources

    GitHub repository with 301,315 stars and 28,045 forks.

    Trending score: 4.60; stars gained: +518; forks gained: +24.

    Language: Python

    Topics: awesome, python, collections, python-frameworks, python-libraries, python-tools

  7. 7. anthropics/claude-plugins-official

    Official, Anthropic-managed directory of high quality Claude Code Plugins.

    GitHub repository with 29,367 stars and 3,147 forks.

    Trending score: 4.59; stars gained: +182; forks gained: +33.

  8. 8. langchain-ai/langchain

    The agent engineering platform.

    GitHub repository with 138,521 stars and 22,951 forks.

    Trending score: 4.53; stars gained: +171; forks gained: +31.

    Language: Python

    Topics: ai, anthropic, gemini, langchain, llm, openai

  9. 9. mukul975/Anthropic-Cybersecurity-Skills

    754 structured cybersecurity skills for AI agents · Mapped to 5 frameworks: MITRE ATT&CK, NIST CSF 2.0, MITRE ATLAS, D3FEND & NIST AI RMF · agentskills.io standard · Works with Claude Code, GitHub Copilot, Codex CLI, Cursor, Gemini CLI & 20+ platforms · 26 security domains · Apache 2.0

    GitHub repository with 13,233 stars and 1,551 forks.

    Trending score: 4.53; stars gained: +301; forks gained: +38.

    Language: Python

    Topics: ai-agents, claude-code, cybersecurity, incident-response, mitre-attack, penetration-testing

  10. 10. anthropics/knowledge-work-plugins

    Open source repository of plugins primarily intended for knowledge workers to use in Claude Cowork

    GitHub repository with 19,148 stars and 2,241 forks.

    Trending score: 4.44; stars gained: +264; forks gained: +22.

    Language: Python

  11. 11. microsoft/agent-governance-toolkit

    AI Agent Governance Toolkit — Policy enforcement, zero-trust identity, execution sandboxing, and reliability engineering for autonomous AI agents. Covers 10/10 OWASP Agentic Top 10.

    GitHub repository with 3,987 stars and 546 forks.

    Trending score: 4.25; stars gained: +167; forks gained: +12.

    Language: Python

    Topics: agent-framework, ai-agents, ai-safety, compliance, governance, microsoft

  12. 12. CloakHQ/CloakBrowser

    Stealth Chromium that passes every bot detection test. Drop-in Playwright replacement with source-level fingerprint patches. 30/30 tests passed.

    GitHub repository with 23,119 stars and 1,836 forks.

    Trending score: 4.24; stars gained: +250; forks gained: +17.

    Language: Python

    Topics: anti-detect, bot-detection, browser-automation, chromium, cloudflare, fingerprint

  13. 13. microsoft/SkillOpt

    SkillOpt is a text-space optimizer that trains reusable natural-language skills for frozen LLM agents through trajectory-driven edits, validation-gated updates, and deployable best_skill.md artifacts.

    GitHub repository with 4,942 stars and 492 forks.

    Trending score: 4.23; stars gained: +219; forks gained: +26.

    Language: Python

    Topics: agent-skills, self-evolving-agents

  14. 14. HKUDS/nanobot

    Lightweight, open-source AI agent for your tools, chats, and workflows.

    GitHub repository with 43,690 stars and 7,733 forks.

    Trending score: 4.22; stars gained: +132; forks gained: +28.

    Language: Python

    Topics: ai, ai-agent, ai-agents, anthropic, chatgpt, claude

  15. 15. vectorize-io/hindsight

    Hindsight: Agent Memory That Learns

    GitHub repository with 15,667 stars and 889 forks.

    Trending score: 4.22; stars gained: +129; forks gained: +10.

    Language: Python

    Topics: agentic-ai, memory, agents, ai-memory

  16. 16. langchain-ai/langgraph

    Build resilient agents.

    GitHub repository with 33,904 stars and 5,704 forks.

    Trending score: 4.16; stars gained: +211; forks gained: +33.

    Language: Python

    Topics: agents, ai, ai-agents, chatgpt, deepagents, enterprise

  17. 17. Comfy-Org/ComfyUI

    The most powerful and modular diffusion model GUI, api and backend with a graph/nodes interface.

    GitHub repository with 115,736 stars and 13,545 forks.

    Trending score: 4.13; stars gained: +292; forks gained: +39.

    Language: Python

    Topics: ai, comfy, comfyui, python, pytorch, stable-diffusion

  18. 18. BlazeUp-AI/Observal

    Observal is a unified platform for agent distribution, observability and insights.

    GitHub repository with 1,994 stars and 374 forks.

    Trending score: 4.07; stars gained: +119; forks gained: +63.

    Language: Python

    Topics: cli-tool, evaluation, large-language-models, llm, llm-evaluation, llm-observability

  19. 19. google-deepmind/science-skills

    GDM Science Skills to speed up agentic scientific workflows with better grounding and higher token efficiency. Integrate insights from AlphaGenome, AFDB, UniProt and 30+ other databases and tools.

    GitHub repository with 1,558 stars and 151 forks.

    Trending score: 4.07; stars gained: +271; forks gained: +24.

    Language: Python

  20. 20. BerriAI/litellm

    Python SDK, Proxy Server (AI Gateway) to call 100+ LLM APIs in OpenAI (or native) format, with cost tracking, guardrails, loadbalancing and logging. [Bedrock, Azure, OpenAI, VertexAI, Cohere, Anthropic, Sagemaker, HuggingFace, VLLM, NVIDIA NIM]

    GitHub repository with 49,340 stars and 8,612 forks.

    Trending score: 4.07; stars gained: +250; forks gained: +59.

    Language: Python

    Topics: ai-gateway, anthropic, azure-openai, bedrock, gateway, langchain

  21. 21. ComposioHQ/awesome-codex-skills

    A curated list of practical Codex skills for automating workflows across the Codex CLI and API.

    GitHub repository with 12,933 stars and 1,258 forks.

    Trending score: 4.00; stars gained: +197; forks gained: +21.

    Language: Python

    Topics: codex, codex-cli, codex-skills, coding-agent-skills, coding-agents, gpt-5-1-codex

  22. 22. EbookFoundation/free-programming-books

    :books: Freely available programming books

    GitHub repository with 389,694 stars and 66,414 forks.

    Trending score: 3.98; stars gained: +169; forks gained: +19.

    Language: Python

    Topics: education, books, list, resource, hacktoberfest

  23. 23. Tracer-Cloud/opensre

    Build your own AI SRE agents. The open source toolkit for the AI era.

    GitHub repository with 6,399 stars and 857 forks.

    Trending score: 3.96; stars gained: +82; forks gained: +23.

    Language: Python

    Topics: ai-sre, alerting, datadog, grafana, incident-management, observability

  24. 24. opensquilla/opensquilla

    OpenSquilla — Token-Efficient AI Agent with same budget, higher intelligence density

    GitHub repository with 3,036 stars and 217 forks.

    Trending score: 3.92; stars gained: +201; forks gained: +18.

    Language: Python

    Topics: agent, ai, ai-agents, deep-learning, foundation-models, llm